Plants have long produced potent human therapeutics and contributed to over 20% of drugs approved since the 1980s, including Morphine and Artemisinin. Although monoterpene indole alkaloids (MIAs), a promising class of plant-derived compounds with unique pharmacological properties that have already produced drugs such as the chemotherapy vinblastine, could help to…

Despite the many alternative flavors of NoSQL databases that have caught the attention of developers over the years, relational databases remain the de facto standard for storing and retrieving digital information. Every technology worker from the back-office IT personnel to the modern Web developer has been trained to use, manage…

In 2021, the US Department of Defense spent $142 billion on procurement and $106 billion on developing new technologies (RDT&E) — while global defense spending reached over two trillion dollars. Yet the US and its allies are potentially dangerously wrong-footed by having over-spent on legacy hardware systems (eg aircraft carriers…

As new tooling, entrepreneurial accessibility and AI continue to unlock evolution’s algorithms, programmable biology is moving from vision to reality at increasing speed. To foster conversations and share insights, we have teamed up with EQT and Obvious Ventures and are pleased to be hosting an intimate, invite-only dinner for founders…

As humans age the chances of dying from specific diseases (cancer, coronary, neurological, etc.) increase, where the rate of aging is controlled by genetic pathways and biochemical processes conserved in evolution. Although the hallmarks of aging (including several cellular and molecular processes such as genomic instability, telomere attrition, stem cell…

Due to abnormal metabolism, certain diseased tissues, most notably solid tumors, produce an acidic extracellular microenvironment that is still little understood. Nevertheless, today all drugs in oncology are developed by R&D teams using the same classic textbook definition of tumor acidity which leads to (among other issues) poor tumor targeting…

The explosion in computing resources over the last decade has made it possible for the extremely complex systems of molecular biology to be simulated in high enough fidelity to begin to produce new materials, new drugs and other important substances. However even with increasingly accurate simulation, chemical development today still…

Artificial intelligence has made significant strides in recent years, particularly with the rise of generative AI and large language models (LLMs). These innovations have sparked our collective imagination, turning once fictional concepts into tangible products used by companies at scale. However, the process of training these models is both resource-intensive…

Nanotechnology, core to the $200Bn value-added materials market, has for decades been heralded as one of the most promising areas of science and industry. However, we are yet to discover even 1% of what is possible in nanomaterial design because of the challenges in unlocking the unique properties of elements…